Dosing · Restore · MOTS-C 10MG
Restore · Mitochondrial Peptide

MOTS-C 10MG

A mitochondrial-derived peptide — activates AMPK for metabolic health, stress resilience, and cellular energy.

49,00 € 10 mg vial In stock
Per reference25units
Cadence2–3× per week
Dose2.5mg
Vial10mg / 1 mL
MOTS-C 10MG

About

A mitochondrial-derived peptide encoded within mitochondrial DNA - the body's own metabolic regulator.

Research describes MOTS-C as activating AMPK, the master energy-sensor enzyme. Literature notes effects on metabolic flexibility, insulin sensitivity, fat oxidation, and stress resilience. Endogenous MOTS-C levels decline with age — a pattern the peptide reverses.

Sequence lists MOTS-C under the Restore category - longevity, cellular energy.

Vial content

10 mg lyophilised MOTS-C in an amber vial at 10 mg/mL after reconstitution.

At reference, 25 units on a U-50 insulin syringe draws approximately 2.5 mg. Some research protocols use higher doses (5–10 mg weekly) split across 2–3 injections.

Storage: refrigerated 2–8°C after reconstitution. Do not freeze.

Reported effects

What the literature
describes.

01

AMPK activation

02

Insulin sensitivity

03

Fat oxidation & metabolic flexibility

04

Stress resilience

05

Cellular energy & longevity

Reported timeline

What the literature
reports, by phase.

Week 1–2
01

Week 1–2 — Steadier energy through the day. Reduced post-meal crashes.

Week 3–6
02

Week 3–6 — Metabolic flexibility improves — the body shifts between fat and glucose more efficiently.

Week 6–12
03

Week 6–12 — Insulin markers trend. Exercise recovery improves. Mitochondrial biogenesis signs.

Long-term
04

Long-term — Retained metabolic baseline post-cycle. Literature links to age-reversal markers.

Reference dosing

Reference profile.

Baseline

Standard
25units / dose
2.5 mg · 2× per week
  • Injection siteSubcutaneous · abdomen, thigh, upper arm
  • RotationQuadrant cycle, avoid repeat sites
  • TimingMorning preferred - pairs with daytime energy

Recommended cycle

Two months on. One month off. Up to three cycles annually.

Cycling supports endogenous mitochondrial response. The off-phase tests whether metabolic gains hold on the body's own MOTS-C production.

Vial details

ContentMOTS-C · lyophilised
Mass10 mg
Reconstitution1 mL water
Concentration10 mg/mL
Supply (baseline)~2 weeks at 2× cadence
Storage2–8°C · do not freeze
Mechanism

AMPK. Mitochondria. Cellular energy.

MOTS-C is encoded within mitochondrial DNA - a rare peptide produced by the mitochondrial genome rather than the nuclear one. It activates AMPK (AMP-activated protein kinase), the cellular energy sensor that switches on fat oxidation, autophagy, and mitochondrial biogenesis when energy is low.

The result is metabolic flexibility - the capacity to shift between fuel sources efficiently. Declines with age; reversible with exogenous MOTS-C.

  • AMPKMaster energy-sensor enzyme — switches on when ATP is low.
  • Fat oxidationPreferential use of fat for energy; reduces fat storage.
  • AutophagyCellular cleanup of damaged components.
  • BiogenesisNew mitochondria produced — cellular energy capacity expands.
Safety signals

Reported side effects
& contraindications.

Reported side effects
  • Injection-site redness or mild discomfort
  • Transient headache
  • Mild nausea (rare)
  • Occasional fatigue during first week
Contraindications
  • Active malignancy
  • Pregnancy or breastfeeding
  • Known peptide or excipient hypersensitivity
Discontinue and seek medical advice

Severe swelling, fever above 38°C, worsening fatigue, rash, breathing difficulty, or facial swelling — discontinue and contact a clinician.

Research chemical · Not for human consumption. This reference is educational only. Sequence does not provide medical services or prescribe. Consult a licensed clinician for any health decision.

Watch it done properly.

Reconstitution, site rotation, storage — on video.

Video guide Back to dosing